You can now submit reviews for your favorite Tocris products. Save: $128.14 (69%) 6 new from $56.86 & FREE Shipping. Steptozotocin: A review of its pharmacology, efficacy and toxicity. 1,2 It specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown: The Adooq molarity calculator is a useful tool which allows you to calculate the: *When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online). The technical data provided above is for guidance only. The Adooq molarity calculator is based on the following equation: Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol). Weis (1982) Steptozotocin: A review of its pharmacology, efficacy and toxicity. Our Cancer Research Guide highlights over 750 products for cancer research. 1272/2008 1.1 Product Code: 13104 Section 1. Orders valued at $300, will receive 300 points. Registered codes will be associated with your order and points will be awarded ($1 = 1 point). As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally. Evaluation of Anti-hyperglycemic Effect of Sub-fractions Derived from Ethanol-aqueous Fraction of Balanites aegyptiaca Leaves in Streptozotocin-induced Diabetic Rats, Asian J Exp Biol Sci, 2019, 12 (2): 164-172, Stanley I. R. Okoduwa, .et al. *Please note that Tocris will only send literature to established scientific business / institute addresses. CAS Number 18883-66-4. Your 2786 PMID: 6454479, Weis Preparation: Reconstitute ZANOSAR with 9.5 mL of dextrose injection USP, or 0.9% sodium chloride injection USP. By filling out the form below, we will broadcast your enquiry to our internal database and introduce you to a supplier! Antibiotic and antitumor agent. Streptozocin, a diabetagen, is especially toxic to … The streptozotocin-induced diabetic nude mouse model: differences between animals from different sources. Do you know of a great paper that uses Streptozocin from Tocris? Bioz Stars score: 99/100, based on 2105 PubMed citations. C10H16N2O2 c10h16n2o2. 61(4):356-60. Alloxan is a cyclic urea analog that is chemically similar to streptozotocin. Calculate the dilution required to prepare a stock solution. We invite you to request* your copy today! Cancer Res. Product Name Form Components Specificity of Inhibition; HY-K0021: Phosphatase Inhibitor Cocktail I: Solution (100× in DMSO) (-)-p-Bromotetramisole oxalate, Cantharidin, Microcystin LR (Microcystis aeruginosa)Alkaline phosphatases, Ser/Thr phosphatases, PP1 and PP2A Streptozotocin (STZ), first described as a broad-spectrum antibiotic possessing antitumor, oncogenic, and diabetogenic properties, was initially isolated from Streptomyces achromogenes in the 1960s, after which it was proved to be diabetogenic. Bio-Techne & Earn an Amazon Gift Card, O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(N(C)N=O)=O. decide on the best products for their research. Streptozotocin, supplied by Millipore, used in various techniques. Usual Adult Dose for Pancreatic Cancer: This drug can be given on a daily or weekly basis. Streptozotocin je organsko jedinjenje, koje sadrži 8 atoma ugljenika i ima molekulsku masu od 265,221 Da. 41 2786 PMID: 6454479 . More>>, Streptozotocin (Zanosar) Chemical Structure, Free Overnight Delivery on orders over $500. Streptozotocin or streptozocin (INN, USP) (STZ) is a naturally occurring alkylating antineoplastic agent that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. Free shipping on inhibitor and protein orders over $500. What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution? Send out an enquiry for this chemical/service. Selective pancreatic β-cell toxin. Streptozotocin is an N-nitroso-containing compound that induces death of insulin-secreting cells, producing an animal model of diabetes. Editor's note: Some chemicals in this database contain more information than others due to the original reason this information was collected and how the compilation was accomplished. ALX appeares not to be toxic for the studied cell lines with estimated IC 50 values of 2809, 3679 or over 4000 μg/mL for HL60, K562 and C1498 cells, respectively. Sigma-Aldrich offers a number of Streptozocin products. Streptozotocin is widely used to induce T1DM in animal models, such as rats and mice. *When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online). Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival. The manganese content in the pancreas, spleen, and kidney of streptozotocin-manganese-treated rats were much lower than those in the tissues in group 3, whereas, those in the brain, thymus, and liver remained unchanged. Tocris offers the following scientific literature in this area to showcase our products. Anti-Diabetic Potential of Ocimum gratissimum Leaf Fractions in Fortified Diet-Fed Streptozotocin Treated Rat Model of Type-2 Diabetes, Medicines (Basel), 2017, Dec; 4(4): 73, Stanley I. R. Okoduwa, .et al. When streptozotocin was given, the blood glucose level rose over 400 mg/dl and stabilized in a few days. The resulting pale-gold solution will contain 100 mg … Use single quotes (') for phrases. Rep. 66 Cancer Treat. It may be injected once a day for 5 days in row every 6 weeks or it may be injected once a week. Osobine. DNA alkylating agent. 41 Comp Med. Not for human use. Streptozotocin (STZ) is a naturally-occurring small molecule (MW=265) that is specifically toxic to pancreatic β-cells. Streptozocin dosing information. The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. MW 265.22, Purity > 95%. High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable, Programmed Cell Death Life Science Poster, Certificate of Analysis / Product Datasheet. Use spaces to separate tags. Citations are publications that use Tocris products. Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Cat. Evaluation of extraction protocols for anti-diabetic phytochemical substances from medicinal plants, World J Diabetes, 2016, Dec 15; 7(20): 605-614, Enter 10 into the Concentration (start) box and select the correct unit (millimolar), Enter 50 into the Concentration (final) box and select the correct unit (micromolar), Enter 20 into the Volume (final) box and select the correct unit (milliliter), The answer of 100 microliter (0.1 ml) appears in the Volume (start) box, mass of a compound required to prepare a solution of known volume and concentration, volume of solution required to dissolve a compound of known mass to a desired concentration, concentration of a solution resulting from a known mass of compound in a specific volume, Enter 197.13 into the Molecular Weight (MW) box, Enter 10 into the Concentration box and select the correct unit (millimolar), Enter 10 into the Volume box and select the correct unit (milliliter), The answer of 19.713 mg appears in the Mass box. S0130 SIGMA Streptozocin ≥75% α-anomer basis, ≥98% (HPLC), powder Quy cách: 50mg Hãng: Sigma Aldrich Add to Cart. Get Get resources and offers direct to your inbox. Streptozotocin is … Average Rating: 5 (Based on 1 Review. We promise all products perform as described. Keywords:buy Streptozotocin (Zanosar) | Streptozotocin (Zanosar) Supplier | purchase | cost | manufacturer | order | distributor | buy 18883-66-4| 18883-66-4 Supplier | purchase 18883-66-4 | 18883-66-4 cost | 18883-66-4 manufacturer | order 18883-66-4 | 18883-66-4 distributor, Check our recent promotion and sale events, AdScreen™ MAPK Inhibitor Compound Library, AdScreen™ PI3K/Akt/mTOR Inhibitor Compound Library, Publications Citing Use of Adooq Streptozotocin (Zanosar), Download Streptozotocin (Zanosar) SD file, D.H. Mhya, .et al. 2012 Priority List for the Development of Proposition 65 NSRLs for Carcinogens and MADLs for Chemicals Causing Reproductive Toxicity buy Streptozotocin - Nono is a leading importer of streptozotocin from Philippines. JavaScript seems to be disabled in your browser. Need Streptozotocin 525 grams for rat study, Chemicals - Ermita, Philippines Posted on: Oct 22, 2009 Valid upto: Apr 22, 2010 Buyer: UP College of Medicine Location: Ermita Philippines 29(6):1110-9. Streptozotocin (Streptozocin, Zanosar, STZ)is used in medical research to produce an animal model for Type 1 diabetes, which directly inhibist the O-GlcNAcase activity of the enzyme NCOAT in vitro. Please supply us with your details below and which chemical/service you are … Alkylation of DNA in rat tissues following administration of streptozotocin. 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