All trials on the list are supported by NCI.. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Bevacizumab may prevent the growth of new blood vessels that tumors need to grow. The clinical trials on this list are for colon cancer treatment. Bevacizumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Included tumor types (a, b) and regional distribution (c) of clinical PD-1 / PD-L1 and CAR T cell trials in 2019.ClinicalTrials.gov was searched for “pd-l1” OR “pd-1” OR “programmed death ligand” OR “car t cell” OR “chimeric antigen receptor”. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Location: 16 locations, CO40939 is a Phase Ib, open-label, multicenter, single-arm study designed to evaluate the safety, efficacy, pharmacokinetics, and immunogenicity of cibisatamab in combination with atezolizumab administered after pretreatment with obinutuzumab in patients with Stage IV microsatellite stable (MSS) metastatic colorectal cancer (mCRC) whose tumors have high carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) expression and who have progressed on two or more chemotherapy regimens. Location: 5 locations, This is a phase II, open-label, non-randomized study in subjects with histologically confirmed diagnosis of left-sided RAS WT advanced adenocarcinoma of the colon or rectum who have not received prior systemic therapy for metastatic disease. Location: 2 locations, This early phase I trial studies how well heated intra-peritoneal chemotherapy with doxorubicin and cisplatin work for the treatment of abdominal or pelvic tumors that can be removed by surgery (resectable), does not respond to treatment (refractory), or has come back (recurrent). Neuroendocrine carcinoma including carcinoid of the lung (closed to accrual 12 / 19 / 2017) 24. Testing for ctDNA levels may help identify patients with colon cancer who benefit from receiving chemotherapy after surgery. Location: 14 locations, CO40939 is a Phase Ib, open-label, multicenter, single-arm study designed to evaluate the safety, efficacy, pharmacokinetics, and immunogenicity of cibisatamab in combination with atezolizumab administered after pretreatment with obinutuzumab in patients with Stage IV microsatellite stable (MSS) metastatic colorectal cancer (mCRC) whose tumors have high carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) expression and who have progressed on two or more chemotherapy regimens. Location: 11 locations, This phase Ib / II trial studies the safety and best dose of cabozantinib-s-malate when given together with panitumumab in treating patients with colorectal cancer that has spread to other parts of the body or cannot be removed by surgery. It involves the infusion of a heated chemotherapy solution that circulates into the abdominal cavity. This condition is now also referred to as adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant adenocarcinoma, or invasive mucinous adenocarcinoma 13. Colorectal cancer vaccine has promising results in early trials. Encorafenib and binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. After completing the questions, you … Transanal mesorectal excision with laparoscopic assistance is a procedure that combines standard laparoscopy, or multiple small abdominal incisions, with surgery through the anus in order to remove rectal cancer, and it may work better in treating patients with rectal cancer. Clinical trials are research studies that involve people. Giving TAS-102, irinotecan, and bevacizumab may work better in treating patients with colorectal cancer compared to traditional chemotherapy and bevacizumab. Location: 13 locations, This is a Phase 1 / 1b open-label, dose escalation and dose expansion study of CPI-006, a humanized monoclonal antibody (mAb) targeting the CD73 cell-surface ectonucleotidase in adult subjects with select advanced cancers. When trastuzumab attaches to HER2 receptors, the signals that tell the cells to grow are blocked and the cancer cell may be marked for destruction by the body’s immune system. Part 2 of the study will further evaluate the RP2D in 3 distinct tumor cohorts of approximately 12 subjects each. When this type of abnormal growth occurs in the colon or rectum, it is called colorectal cancer (CRC). Location: 684 locations, The purpose of this study is to evaluate the dose, safety, immunogenicity and early clinical activity of GRT-C903 and GRT-R904, a neoantigen-based therapeutic cancer vaccine, in combination with immune checkpoint blockade, in patients with advanced or metastatic non-small cell lung cancer, microsatellite stable colorectal cancer, pancreatic cancer, and shared neoantigen-positive tumors. The COBRA trial, which opened to accrual in December 2019, is expected to enroll over 1,400 patients who have resected stage IIA colon cancer that is considered low-risk and would not … This is genetic material unique to the cancer that may be present in the blood stream and can be identified through a ctDNA blood test. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. In the Phase 2 dose expansion portion, patients will be treated with doublet or triplet in the relapsed / refractory setting and earlier lines of therapy. When trastuzumab attaches to HER2 receptors, the signals that tell the cells to grow are blocked and the cancer cell may be marked for destruction by the body’s immune system. When vitamin D binds to the receptor in the cancer cells, it may stop cancer cells from growing abnormally and may cause cell death. The study will be conducted in 2 parts: with Part 1 consisting of dose escalation and Part 2 dose expansion. Squamous cell carcinoma with variants of GI tract (stomach small intestine, colon, rectum, pancreas) (closed to accrual 10 / 17 / 2018) 7. Immunotherapy with monoclonal antibodies, such as pertuzumab and cetuximab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Clear cell cervical cancer 43. Purpose: CALGB/SWOG 80405 was a randomized phase III trial that found no statistically significant difference in overall survival (OS) in patients with first-line metastatic colorectal cancer treated with … Desmoid tumors 28. Gestational trophoblastic disease (GTD) 47. [button] Download the Clinical Trials Mini Magazine [/button] Immunotherapy with monoclonal antibodies, such as panitumumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread Giving cabozantinib-s-malate with panitumumab may work better in treating patients with colorectal cancer. Nov. 25, 2019 — Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a new study. Clinical trials are a type of medical research used to test cutting edge approaches for treating or diagnosing disease, including cancer. Finding ctDNA in the blood means that there are very likely small amounts of cancer remaining after surgery that may not be detectable using other tests, such as medical imaging. Bronchoalveolar carcinoma lung. Location: 1201 locations, This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body (advanced or metastatic). This trial enrolls participants for the following cohorts based on condition: 1. Clinical trials are research studies that involve people. Part 2A of the study will evaluate the safety and tolerability of dostarlimab at fixed doses of 500 mg administered every 3 weeks (Q3W) and 1000 mg administered every 6 weeks (Q6W). Part 2B of the study will examine the safety and clinical activity of dostarlimab in cohorts of participants with specific types of advanced solid tumors. Location: 22 locations, This is a multi-center, open-label, first-in-human Phase 1 study evaluating the anti-programmed death receptor 1 (anti-PD-1) antibody dostarlimab (also known as TSR-042) n participants with advanced solid tumors who have limited available treatment options. Besides an ageing population and dietary habits of high-income countries, unfavourable risk factors such as obesity, lack of physical exercise, and smoking increase the risk of colorectal cancer. Medical oncologist Rona Yaeger (right) studies signaling pathways in colorectal cancer. Talk to your doctor for help in deciding if one is right for you. Malignant giant cell tumors 30. The colon … Location: 15 locations, This is a multicenter, open-label, first-in-human Phase 1 study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. Part 2 of the study will evaluate the antitumor activity of TSR-022, both as monotherapy and in combination with TSR-042 in participants with pre-specified tumor types. Undifferentiated carcinoma of gastrointestinal (GI) tract 5. Clinical trials … Drugs used in chemotherapy, such as TAS-102 and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The study is being conducted in patients with several types of refractory cancers including those at the surface of the skin (breast, squamous cell, head and neck) and tumors within the body such (pancreatic, colon, liver, lung, etc.). Cabozantinib-s-malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. This new triplet combination for BRAF V600e patients includes: 1. Location: 878 locations, This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Heated intra-peritoneal chemotherapy is a procedure performed in combination with abdominal surgery for cancer that has spread to the abdomen. The clinical trials on this list are for colon cancer treatment. Basal cell carcinoma (temporarily closed to accrual 04 / 29 / 2020) 42. It is not yet known whether giving high-dose vitamin D3 in addition to chemotherapy and bevacizumab would extend patients time without disease compared to the usual approach (chemotherapy and bevacizumab). Colorectal cancer … Angiosarcoma 51. All trials on the list are supported by NCI. Location: 911 locations, This randomized phase II trial studies how well trastuzumab and pertuzumab work compared to cetuximab and irinotecan hydrochloride in treating patients with HER2 / neu amplified colorectal cancer that has spread from where it started to other places in the body (advanced / metastatic) and cannot be removed by surgery. Location: 684 locations, This is a Phase 1 / 2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in patients with medullary thyroid cancer, RET-altered NSCLC and other RET-altered solid tumors. NAC for colon cancer improves surgical outcomes and can now be considered as a treatment option; longer follow-up and further trials are required to confirm the long-term benefits, refine its use and optimise case selection. Epithelial tumors of penis - squamous adenocarcinoma cell carcinoma with variants of penis 18. The Colon Cancer Foundation and the American Cancer Society have joined forces on an initiative called 80% in Every Community, which challenges you to take a stand against one of the most preventable forms of cancer – colorectal cancer – by getting screened, choosing a healthy way of eating and being physically active. Adrenal cortical tumors (closed to accrual 06 / 27 / 2018) 32. Drugs used in chemotherapy, such as doxorubicin and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Small cell carcinoma of the ovary, hypercalcemic type 49. Vitamin D3 may also modulate the immune system and is being studied in the prevention and treatment of some types of cancer. Growth factor antagonists, such as regorafenib, may interfere with the growth factor and stop the tumor from growing. Intrahepatic cholangiocarcinoma (closed to accrual 03 / 20 / 2018) 10. The participants in this trial have HER2-positive (HER2+) metastatic colorectal cancer (mCRC). (closed to accrual) 23. Location: 8 locations, This phase II trial studies how well retreatment with panitumumab works compared to standard of care regorafenib or trifluridine and tipiracil hydrochloride (TAS-102) in treating patients with colorectal cancer that is negative for RAS wild-type colorectal cancer has spread to other places in the body (metastatic), and / or cannot be removed by surgery (unresectable), and is negative for resistance mutations in blood. Location: 878 locations, This randomized phase II trial studies how well trastuzumab and pertuzumab work compared to cetuximab and irinotecan hydrochloride in treating patients with HER2 / neu amplified colorectal cancer that has spread from where it started to other places in the body (advanced / metastatic) and cannot be removed by surgery. Location: 12 locations, Study of NGM120 in subjects with advanced solid tumors and pancreatic cancer. This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Cancer was infrequently diagnosed of a heated chemotherapy solution and infusing it directly the. Research studies that involve people patients includes: 1 regorafenib, may interfere with the growth and! ) 31 and ipilimumab in treating patients with colon cancer excluding prostate cancer ) ( closed accrual... Better in shrinking or stabilizing colorectal cancer be an indicator that cancer is a substance made by cells helps... Irinotecan hydrochloride in treating patients with colon cancer treatment most common cause of cancer therapy may an... 11 / 29 / 2020 ) 41 small intestine ( closed to accrual 03 25! 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